Substitution at R3 which has a halogen or alkoxy group (74f–74i) triggered a slight rise in cellular potency Together with the halide analogs (74g–h) displaying greatest the potency while in the group. More optimization led to the invention of 74i–j, with 74k as by far the most Lively compound from https://indazoleproducts31864.thekatyblog.com/30506705/the-2-minute-rule-for-indazole-products