Everyday living-threatening respiratory melancholy and Dying have transpired in kids who been given codeine. A lot of the noted circumstances happened subsequent tonsillectomy and/or adenoidectomy and several of the children had evidence of becoming ultra-fast metabolizers of codeine as a consequence of a cytochrome P450 (CYP) 2D6 polymorphism (see WARNINGS, https://wockusa.com/product/quagen-promethazine-hcl-and-codeine-phosphate-oral-solution/