Injectable codeine is readily available for subcutaneous or intramuscular injection only; intravenous injection is contraindicated, as this may end up in nonimmune mast-cell degranulation and resulting anaphylactoid response. Codeine suppositories also are marketed in some nations around the world. In Eire, new restrictions arrived into effect on 1 August 2010[ninety] https://codeingil.com/